Drug development: Bel/Novamann perspective

By Dr. Miroslav Veverka, Eurofins Bel/Novamann, Slovakia, AndreaCveckova@eurofins.sk, MiroslavVeverka@eurofins.sk

The solid state of a drug is critically important in determining the drug's effectiveness for delivery. Poorly soluble compounds make up roughly 80% of drug candidates in the pharmaceutical industry. Instability, bitter taste, low permeability are examples of other unpleasant obstacles. The solid state treatment affording alternatively solid forms e.g. amorphous, polymorphs, solvates, solid dispersions, co-crystals, inclusion complex resolves these problems.

Eurofins Bel/Novamann R&D group has dealt with many significant projects on new solid forms due to their unique and compelling value intention. The R&D group offers the capacity, breadth of capabilities, innovator product expertise and global coverage to execute effectively on these complex programmes. Eurofins' experts have participated in the Structural Funds of EU. Clients have found state-of-the-art equipment, including XPS, DSC, XRPD, FTIR, LC-MS, ss-NMR and DVS for solid state characterisation. The R&D group has successfully generated co-crystals and inclusion complexes with natural products, including nutraceuticals.

Eurofins Bel/Novamann supports all aspects of drug testing, including dissolution, stability tests, and complete retesting (release). Also Eurofins Bel/Novamann has the infrastructure to support analysis of incoming product. When compendial methods and standards of impurities are not available, it is necessary to undertake method development/validation or integrate methods reported in pharmacopoeias with other tests. These BU laboratories are formed by experienced chemists focused on non-routine services individually tailored to the needs of clients.

For more information, visit www.pharma.eurofins.com.

References

POSTER AWARD of IV. Int. Conf. «Fundamental Bases of Mechanochemical Technologies» Novosibirsk,June 25 - 28, 2013, Russia. Screening for Complexes of beta glucan and arabinogalactan with nutraceuticals via neat Grinding and Crystalization. M. Veverka, J.Galloviè, ¼. Ratkovská, .V. Jorík, P. Šimon, T. Dubaj, M. Mièušík.

M. Veverka, T. Dubaj, J. Galloviè, V. Jorík, E. Veverková, M. Mièušík, P. Šimon. Beta-glucan complexes with selected nutraceuticals: Synthesis, characterization, and stability. J Funct Foods 8 (2014) 309-318.

The 6-th most downloaded articles from ScienceDirect. E.Veverkova, L.Liptakova, M. Veverka, R.Šebesta. Asymmetric Mannich reactions catalyzed by proline and 4-hydroxyproline derived organocatalysts in the presence of water. 2013. Tetrahedron: Asymmetry, 24, 548-552.

P. Šimon, P.Thomas, T. Dubaj, Z.Cibuľková , A.Peller, M.Veverka. The mathematical incorrectness of the integral isoconversional methods in case of variable activation energy and the consequences. 2014. J Therm Anal Calorim 115,853-859.