In Vitro Pharmacology >> Ubiquitin >> DUBs

Deubiquitination

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DUB profiling

Analogous to phosphatases' role in reversing phosphorylation of proteins, the deconjugating enzyme (DCE) proteases, including deubiquitinating enzymes (DUBs), similarly reverse the ubiquitin modification of proteins. By removing ubiquitin from target proteins, DUBs act to oppose the effects of ubiquitination on protein function or targeted destruction by the proteasome.

Advantages of DUB profiling with Eurofins:

  • Key DUBs available, including those relevant for epigenetic modification
  • LanthaScreen® for high assay robustness and reduction of false positives by autofluorescent compounds