GPCRs in Drug Discovery and Safety Pharmacology
G protein coupled receptors (GPCRs), also known as seven transmembrane receptors (7TMs), have been, and will continue to be, prominent drug targets. To support this important area of drug discovery Eurofins Pharma Discovery Services has leveraged the combined expertise from our multiple global sites to create a GPCR Center of Excellence. At our new GPCR Center of Excellence we offer a comprehensive selection of binding and functional GPCR assays to meet the GPCR drug discovery research needs of both chemists and biologists.
In addition to GPCRs for drug discovery Eurofins also has extensive knowledge on the GPCR targets that are relevant for safety pharmacology. Those GPCR targets, along with other safety pharmacology targets, are offered in our SafetyScreen44™ and SafetyScreen87™ services.
Learn more about our GPCR Product and Services
Working with Eurofins for your GPCR research needs you can gain access to:
1. Collaborate with a partner that truly understands GPCRs in Drug Discovery and Safety Pharmacology ✚
Eurofins is the most used and most Trusted GPCR fee-for-service provider in the Pharma Industry survey segment – GPCR Screening and Profiling Trends, HTStec Limited, 2013
2. Conduct your GPCR Research any way you’d like ✚
Our GPCR services, that may be customized or run in HTS format, include hundreds of targets that represent over 65 GPCR families. In addition to our services you can confidently conduct research in your lab with our high-quality/validated selection of GPCR cell lines or membrane preps that we’ve provided to the pharmaceutical industry for years.
3. Access to a wide range of Therapeutic Areas in our GPCR portfolio ✚
Our portfolio of GPCR products and services has targets that are relevant for a diverse set of therapeutic areas such as CNS/Pain, Addiction, Oncology, Metabolism and many others. Along with GPCRs, we offer other services to support drug discovery in all of these therapeutic areas.
4. Elucidate Mechanism of Action (MOA) by researching both the binding affinity and biological impact of your compound ✚
Work with a single service provider that offers hundreds of both Radioligand Binding and Functional assays to research the binding affinity and biological mechanisms of your compound respectively.
5. Determine the correlation between receptor binding and intracellular signaling ✚
Choose from our broad range of Functional Assay readouts that cover primary receptor activation with GTPγS assays and multiple secondary message pathways that include – cAMP, IP3 and Calcium Flux.
6. Have your projects managed by our highly experienced technical and client support teams ✚
Our team has decades of experience working with GPCRs, in addition to other areas of in vitro pharmacology. With both a global GPCR Center of Excellence, and regional business support, all of your GPCR projects will receive personalized attention.
7. Profile your compound with confidence from Drug Discovery through to Safety Pharmacology ✚
Eurofins offers the industry gold standard SafetyScreen44™ panel to identify potential off-target interactions. The panel includes GPCRs, Transporters, Ion Channels, Nuclear Receptors and Kinase targets. Our SafetyScreen87™ panel includes a larger selection of targets to more extensively research a compound.