Hereditary cancer screening
The two most common hereditary cancer syndromes are:
Hereditary breast and ovarian cancer (HBOC) syndrome
Hereditary breast and ovarian cancer (HBOC) syndrome is caused by a pathogenic BRCA1 or BRCA2 gene variant and characterised by increased risk for female and male breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, melanoma and other cancers.
Eurofins Clinical Diagnostics provides a BRCA1/2 long read sequencing analysis of both exonic and intronic regions, detecting point variants, indels, and copy number variations. This analysis determines whether PARP inhibitors are prescribed in the treatment of some types of ovarian, breast, pancreatic and prostate cancer, thus playing a crucial role in cancer management.
Lynch syndrome
Lynch syndrome is caused by a pathogenic gene variant of one of five genes: MLH1, MSH2, MSH6, PMS2 and EPCAM. Lynch syndrome is characterised by an increased risk for colorectal, endometrial and other cancers.
Gene Panels that test for known causal mutations
Scientists have found hundreds of DNA and genetic changes (also called variants, mutations, or alterations) that can be passed down to a child in a parent's egg or sperm cells. Inheriting a cancer-related genetic change doesn’t mean that person will definitely get cancer but it increases their risk. Gene panels provide a list of known disease-causing genes, increasing the chances of finding the causal mutation. We offer 9 Gene Panels:
| Breast/Ovary & Prostate panel (15 genes) | Digestive Tube panel (14 genes) |
| Pancreas panel (16 genes) | Kidney panel (20 genes) |
| Skin panel (16 genes) | Lung panel (15 genes) |
| Neuroendocrine panel (28 genes) | Extended oncogenetic panel (75 genes) |
| Retinoblastoma (RG1 gene study) |
Other genetic tests
The two most common mutations of the MTHFR gene are C677T and A1298C, with up to 50% of the general population carrying at least one of these variants. In some instances, individuals with two copies of the mutation (homozygous) experience less efficient enzyme function, leading to a build-up of homocysteine in the blood, a risk of heart disease (blood clots or stroke), and pregnancy complications.
Find a local laboratory
Three Rock Road, Sandyford Industrial Estate, Dublin,D18 A4C0, Ireland