Posters
Comparative Performance of Bio-Rad QX200 and VibroJet DQ24 ddPCR Platforms for BRAF V600E Detection
Compares ddPCR systems for BRAF V600E detection, highlighting differences in sensitivity, automation, throughput, and precision.
Comparison of Novel Whole Blood Preservation Methods as Alternatives to Cryopreserved PBMC for Immunophenotyping in Multicenter Clinical Trials
Comparative Analysis of Replication-Competent Vector Quantification: Whole Blood vs. PBMCs in Gene Therapy Monitoring
Shows whole blood providing higher sensitivity and easier handling than PBMCs for RCL quantification, offering a faster, practical alternative with comparable accuracy.
The Impact on Method Performance When mAb Are Removed from a Spectral Immunophenotyping Panel
Comparing 26- and 13-color panels showed the smaller panel maintained precision and agreement for key immune populations, supporting its use in streamlined clinical assays.
Evaluating Novel Whole Blood Preservation Methods as Alternatives to PBMC for Immunophenotyping in Multicenter Clinical Trials
CryoStor CS10 showed the most consistent results among whole blood preservation methods, offering a viable alternative to PBMCs in multicenter trials.
Comprehensive AAV-based Vector Shedding Assessment by PCR: A Case Study With Whole Blood, Serum, Semen, Urine, and Buccal Swab
Validated qPCR assays detected AAV vector shedding across five body fluids, highlighting the importance of reagent quality control for accurate gene therapy monitoring.
The Importance of Pairing a Matrix with a Nucleic Acid Extraction Approach - Compilation of 66+ Bioanalytical PCR (qPCR and dPCR) Validations
Analysis of 66+ PCR validations showed optimal matrix-platform pairing is critical for precision and low limits of detection in bioanalysis.
Comprehensive Evaluation of Multiple Automated High Throughput Extraction Platforms Using qPCR Assays
Assessed extraction platforms across serum, plasma, urine, and PBMCs to identify optimal methods for high-throughput qPCR workflows.
Development and Validation of a Novel ECL Method for the Quantitation of Complement C3a/C3a desArg in Human Plasma
Developed and validated a sensitive ECL immunoassay to reliably measure C3a/C3a desArg in human plasma.
Development and Validation of a Novel ECL Method for the Quantitative Detection of Complement C3 in Human Serum
Validated an ECL method for precise quantitation of complement C3 in human serum samples.
Development and Validation of Pharmacokinetic (PK) Assay for a Biparatopic Antibody
Developed and validated pharmacokinetic assays for a biparatopic antibody to support clinical study needs.
Quantitation of Replication Competent Retroviruses and Replication Competent Lentiviruses using Validated Quantitative Real Time PCR Assays
Designed and validated qPCR assays to detect replication-competent retroviruses and lentiviruses in therapeutic T cells.
Challenges in the Transfer of Complex Assay Formats
Explores solutions for transferring complex bioanalytical assays while maintaining precision and reproducibility.
Development of Method for Detection of Anti-Drug Antibodies to Bevacizumab in the Presence of Soluble VEGF
Developed a robust method to measure ADAs against bevacizumab despite interference from soluble VEGF.
Overcoming Challenges for Flow Cytometry in Clinical Regulated Biomarker Analysis
Addresses strategies for accurate, reproducible flow cytometry in regulated clinical studies.
Phenotypic Characterization of Leucine-rich Repeat Kinase 2 (LRRK2) Knockout Rat Model: A Multi Parameter Cross Platform Biomarker Study
Performed multi-parameter biomarker analysis to characterize the LRRK2 knockout rat model across platforms.
Validating Flow Cytometry Assays for Use During Clinical Trial Biomarker Assessments
Presents methods to confirm flow cytometry assay reliability for clinical trial biomarkers.
Recommendations for Demonstrating Equivalency of Ready to Assay Cells in Neutralizing Antibody (NAb) Methods Post-Validation
Provides recommendations for demonstrating equivalency of ready-to-assay cells post-validation in NAb assays.
Immunogenicity analysis: Challenges and Solutions for PEGylated Biopharmaceuticals
Highlights challenges and solutions in evaluating immunogenicity of PEGylated therapies.
A Quick and Efficient Approach to Immunogenicity Assay Development and Optimization Using Design of Experiments
Shows a fast, efficient approach to optimizing immunogenicity assays with design of experiments.
Novel Approach to Immunogenicity Testing for Therapeutics With High Prevalence of Pre-Existing Antibodies
Highlights strategies for testing immunogenicity in therapeutics affected by pre-existing antibodies.
Development and Qualification of PK and ADA Methods for Biosimilar Trastuzumab
Demonstrates development of pharmacokinetic and anti-drug antibody assays for biosimilar Trastuzumab.
GLP Validation of a Gyrolab® Assay for the Determination of Interleukin 8 (IL-8) Levels in Cynomolgus Monkey Serum
Shows GLP validation of a Gyrolab® assay measuring IL-8 levels in cynomolgus monkey serum.
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