Radiolabelled compounds are routinely used to generate data required for the registration of pesticides and other chemicals, under guidelines published by the OECD and the OCSPP (EPA)

Our radiolabelled compounds are used in regulatory studies performed by our environmental, consumer and human safety departments. 

Our radiochemists combine detailed knowledge of the special aspects of radiochemistry with excellent synthetic strategies, robust design and efficient execution to achieve timely and cost effective product delivery.

Our services include:

  • 14C Radiosynthesis including de novo development of synthetic routes
  • Specialised radiosynthesis services for fermentation-derived materials and UVCB substances
  • Chiral separation and salt formation
  • Rapid re-purification service
  • Storage and management of radiolabelled compounds for clients
  • Safe and fast shipment worldwide to multiple destinations if required
  • Comprehensive analytical data package, including full spectroscopic analysis and experimental documentation
  • Full Certificate of Analysis specifying chemical, as well as radiochemical purity by NMR, MS, radio-HPLC and radio-TLC (where appropriate)
  • GLP certification, if required for regulatory submission

We can also provide custom synthesis of metabolites, impurities and reference standards

Our chemists are experienced in carrying out multi-step syntheses across the spectrum of compound classes, compound properties and enabling reactions including:

  • Asymmetric synthesis of compounds containing single and multiple chiral centres using reagent and substrate control supported by preparative chiral HLPC
  • Modification and simplification of complex natural products by total synthesis or degradation/partial synthesis of fermentation products
    • e.g. macrolides, polyketides, terpenes and steroids, flavonoids, antibiotics and secondary metabolites
  • Modern and traditional oganometallic chemistry
    • e.g. Metathesis (Grubs, Hoveyda) and modern transition metal catalysed coupling reactions
  • Orthogonal protecting group strategies.
  • High pressure syntheses, e.g., carbonylations
  • Modern methods for introduction of fluorine
  • Peptide couplings and cyclisations
  • Macrolactonisation/lactamisation
  • Continuous-flow microchemistry (H-cube)
  • Lipids
  • Aminoacids
  • Carbohydrates
  • Heterocyclic chemistry
  • Microwave assisted reactions