Eurofins Agroscience Services offers a broad spectrum of analytical services needed for the registration of agrochemicals and biocides
As exposure to many chemicals occurs mainly via contact with the skin, knowledge of this percutaneous absorption is required by the authorities and is essential to assess the operator exposure.
Eurofins Agroscience Services offer dermal absorption studies. With more than 10 years of expertise in pharmaceutical and cosmetology research areas, the dermal absorption team is composed of technical experts and is located in Vergèze (Gard, France). Over the last 2 years, more than 70 studies for agrochemical substances were conducted for about 15 companies.
Based on the EFSA Journal 2012 Guidance, OECD Guidance document N° 28, OECD Guidance Notes on Dermal Absorption, OECD Guideline Test No. 428 and OECD Guideline Test No. 427, we conduct:
In vitro studies on human or rat skin using:
- static cells
- or flow-through cells
We are also offering a new test to save time in the selection of the formulation which shows the most favorable absorption profile: the dermal absorption screening test.
The screening test will be performed on dermatomed human skin samples from one single donor with at least two replicates per tested formulation. Skin integrity will be determined and formulation preparation will be validated before application. The study design will be developed together.
For further information on dermal absorption studies, please contact Jeanne Bernal Dorange