Solubility and Intrinsic Dissolution Screening
Starting materials, intermediates and API’s solubility are essential information required to optimize different steps of a manufacturing process. Utilizing high-throughput robotic technology and in-house analytical capabilities, we offer fast and accurate solubility screenings in a large number of solvents while using minimum quantity of material and solvents.
Solubility and dissolution are also key parameters that control rate and extent of drug absorption and its bioavailability. Our miniaturized disk IDR apparatus from Pion can produce highly reproducible intrinsic dissolution results using in situ fiber optic UV measurements. Through the solubility and intrinsic dissolution studies, potential bioavailability challenges of a compound can be identified far earlier during the development of new chemical entities, which could help our clients to reach their critical decision point faster.
Related instruments: Unchained Labs Junior™, HPLC/UPLC units, Pion™