Diastereomeric crystallization is a chiral resolution technique based on differences that diastereomers or diastereomeric salts of enantiomers exhibit in their physicochemical properties such as different solubility. Utilizing High-Throughput Screening (HTS) technologies, we are able to identify these differences in a variety of different solvents and choose best solvent candidates to develop our diastereomeric crystallization.
To employ a knowledge-based crystallization development, we determine solubility curve, cloud curve and metastable zone for the desired diastereomer in chosen solvents utilizing medium-throughput instrumentation (Crystal16™) which requires minimum amount of material. Crystallization process itself is monitored by in-line monitoring technologies (e.g. FBRM) through the development stage to maximize selectivity and yield.
Related instruments: Crystal16™, Unchained Labs Junior™, EasyMax™, ParticleTrack G400™, D8 Discover™, D2 Phaser™