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Small Molecules - API Development & Manufacturing >> Solid State Research and Development >> Chiral Resolution

Chiral Resolution

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Diastereomeric crystallization is a chiral resolution technique based on differences that diastereomers or diastereomeric salts of enantiomers exhibit in their physicochemical properties such as different solubility. Utilizing High-Throughput Screening (HTS) technologies, we are able to identify these differences in a variety of different solvents and choose best solvent candidates to develop our diastereomeric crystallization. To employ a knowledge-based crystallization development, we determine solubility curve, cloud curve and metastable zone for the desired diastereomer in chosen solvents utilizing medium-throughput instrumentation (Crystal16™) which requires minimum amount of material. Crystallization process itself is monitored by in-line monitoring technologies (e.g. FBRM) through the development stage to maximize selectivity and yield.

Related instruments: Crystal16™, Unchained Labs Junior™, EasyMax™, ParticleTrack G400™, D8 Discover™, D2 Phaser™

 

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