Clinical efficacy
Index:
This list is not exhaustive. Eurofins can perform customized developments to your existing protocols or develop new ones from scratch.
Skincare
Moisturization
|
Title |
Instrumental assessment of the immediate or cumulative moisturizing efficacy |
|
Objective |
To assess the efficacy of a product on the hydration level of the upper layers of the epidermis after single or repeated applications Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: 1 day for immediate efficacy and XX days for cumulative efficacy. (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurement of the skin capacitance using Corneometer ®, Moisturemeter®D and/or skin water content. Picture with Visioscan® V98 |
|
Procedure |
Immediate efficacy: Basal corneometric measurements on 2 sites Controlled application of the product to one site Post treatment corneometric measurements on test and control sites (kinetics: 30 min. / 2h / 4h / 6h / 8h /10h /12h /24h and/or 48h) Statistical comparison of the results obtained on the control and test sites at each experimental time Cumulative efficacy: Basal corneometric measurements Use of the product at home by the subjects following the instructions for use Post treatment corneometric measurements Statistical comparison of the results obtained before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Intermediate controls |
|
Production laboratory |
|
Skin Barrier Function / Protection
|
Title |
Instrumental assessment of the efficacy on the skin barrier function |
|
Objective |
To assess the effects of a product on the skin barrier function after single or repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: XX days (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurement of the transepidermal water loss (TEWL) (Tewameter® or VapoMeter®, or Evaporimeter Ep-1) reflecting stratum corneum barrier functions |
|
Procedure |
Immediate efficacy: Basal TEWL measurements on 2 sites Controlled application of the product to one site Post treatment TEWL measurements on test and control sites (kinetics: 30 min. / 2h / 4h / 6h / 8h /10h /12h 24h and/or 48h) Statistical comparison of the results obtained on the control and test sites at each experimental time Cumulative efficacy: Basal TEWL measurements Use of the product at home by the subjects following the instructions for use Post treatment TEWL measurements Statistical comparison of the results obtained before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Intermediate controls |
|
Production laboratory |
|
Soothing Effect on SLS induced redness
|
Title |
Instrumental assessment of the soothing efficacy after induction of erythema by application of SLS solution under occlusive patch |
|
Objective |
To assess the soothing efficacy of a product versus a reference product after repeated applications to skin previously irritated by application of SLS solution under occlusive patch |
|
Schedule |
Duration of the study: 24 hours Beginning: 3 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Colorimetric measurement by means of Spectrophotocolorimeter® or Mexameter® or Colorimeter® of the erythematous skin reaction induced by application of diluted solution of Sodium Laury Sulfate (2%) under occlusive patch, and evolution over the time after product application |
|
Procedure |
Preselection-test to determine volunteers presenting with reactivity to SLS, under a Dermatologist control* (at least 7 days before the beginning of the study) Erythema induction on a predefined area on the volunteer’s forearm by applying diluted solution of Sodium Lauryl Sulfate (2%) under a Finn Chamber occlusive patch for 24 hours (1 test site by tested product, one SLS control area, one water control area) Patches removal 24 hours after the patches application (the volunteer’s forearm is gently rinsed with water and dried out with a tissue by slight pressure) Basal colorimetric measurements on the experimental sites (1 test site and 2 control sites) Standardized tested product application (20µL) on the induced erythema on the tested site Colorimetric measurements on each experimental sites (test and control) at different kinetics (30 minutes, 2h, 4h and 24h after application for example) Statistical comparison of the results obtained with and without treatment for each product, at each experimental time *Optional |
|
Production laboratory |
|
Soothing Effect: Anti-Redness / Anti-Red Blotches
|
Title |
Instrumental assessment of the soothing efficacy on pre-existing skin redness |
|
Objective |
To assess the soothing/anti-redness efficacy of a product after repeated applications |
|
Schedule |
Duration of the study: XX days Beginning: 3 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Colorimetric measurement by means of Spectrophotocolorimeter® or Mexameter® or Colorimeter® of the erythematous skin reaction (non-immunological reaction) induced by a short UVB exposure and evolution over the time after product application or pictures with Visia CR® |
|
Procedure |
Colorimetric measurements or pictures with Visia CR® Application of the product Statistical comparison of the results obtained before and after treatment |
|
Production laboratory |
|
Soothing Effect: Stinging Test
|
Title |
Assessment of the soothing efficacy |
|
Objective |
To assess the non-stinging efficacy of a product after single application under controlled conditions |
|
Schedule |
Duration of the study: 3 days Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after end of the study |
|
Methodology |
Self-evaluation of the stinging intensity according to an ordinal scale, or using Spectrophotocolorimeter® |
|
Procedure |
Basal stinging test: - Facial sauna for 15 minutes - Application of a 10% lactic acid aqueous solution to one nasogenian fold and application of a 0.9% sodium chloride aqueous solution to the other nasogenian fold - Self-assessment by the subjects of the stinging intensity within 5 minutes after application of each solution Application of the product 2 days later Post application stinging test Statistical comparison of the results obtained before and after product application |
|
Production laboratory |
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Dermo-Protection
|
Title |
Instrumental assessment of the dermo-protective efficacy |
|
Objective |
To assess the dermo-protective efficacy of a product after single application under controlled conditions |
|
Schedule |
Duration of the study: 1 day Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after end of the study |
|
Methodology |
Assessment of the stratum corneum integrity by measurement of the transepidermal water loss (TEWL) (Tewameter® or VapoMeter®, or Evaporimeter®) |
|
Procedure |
Basal measurements of TEWL on 2 sites Application of the product at the investigating centre to one site 1 or 2 or 3 hour-post application TEWL measurements on the test and control sites Statistical comparison of the results obtained on the control and test sites before and after application |
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Production laboratory |
|
Skin Temperature
|
Title |
Assessment of the cooling / warming efficacy |
|
Objective |
To assess the cooling/warming efficacy of a product after single application under controlled conditions |
|
Schedule |
Duration of the study: 1 day Beginning: 2 weeks upon receipt of the samples Report: 2 weeks after the end of the study |
|
Methodology |
Measurement of the skin temperature by means of Infrared Camera ThermaCAM®B2 or Infrared Camera FLIR® system or infrared thermometer (Fluke® 566) or Skin Thermometer® ST 500 |
|
Procedure |
Controlled acclimatization period Measurement on the 2 defined sites Application of the product to one site Post application measurement on both test and control sites Statistical comparison of the results obtained at each experimental time on the control and test sites |
|
Production laboratory |
|
Protection against cold
|
Title |
Assessment of the protection against cold |
|
Objective |
To assess the protection against cold of a product after single application under controlled conditions |
|
Schedule |
Duration of the study: 1 day Beginning: 2 weeks upon receipt of the samples Report: 2 weeks after the end of the study |
|
Methodology |
Measurement of the skin temperature by means of Infrared Camera ThermaCAM®B2 or Infrared Camera FLIR® system or infrared thermometer (Fluke 566) or Skin Thermometer® ST 500 |
|
Procedure |
Controlled acclimatization period Measurement on the 2 defined sites Application of the product to one site Exposition of the 2 sites to cold Post application measurement on both test and control sites Statistical comparison of the results obtained at each experimental time on the control and test sites |
|
Production laboratory |
|
Skin Viscoelastic Properties (Firmness / Suppleness / Elasticity / Tonicity / Tensor / Lift)
|
Instrumental assessment of the efficacy of a cosmetic product on the skin viscoelasticity |
|
|
Objective |
To assess the skin viscoelastic properties after a product application in normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: 1 day or several days depending on the product efficacy Beginning: 2 weeks upon receipt of the samples Report: 4 weeks after the end of the study |
|
Methodology |
Measurement of the skin viscoelastic properties using a Cutometer® |
|
Procedure |
Basal cutometric measurements Single application of the product at the investigating centre or repeated applications at home Immediate post application cutometric measurements on both test and control sites or after X days of daily application Statistical comparison of the results obtained before and after product application and on the test and control sites Optional: cosmetic qualities and efficacy questionnaire |
|
Production laboratory |
|
Anti-Wrinkles
|
Title |
Instrumental assessment of the anti-wrinkle efficacy |
|
Objective |
To assess the anti-wrinkle efficacy of a product after repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: XX days (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Analysis of Silflo® replicas of the crow’s feet wrinkles with the Quantirides®/ Quantilines® software or Visioline® VL 650 software or fringes projection analysis with Dermatop HE® or AEVA® |
|
Procedure |
Basal skin replica. Measurement with fringe projection device Use of the product at home by the subjects following the instructions for use Post treatment replicas of the same crow’s feet wrinkles and measurement Analysis of the parameters of the wrinkles Statistical comparison of the results obtained before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Professional pictures Intermediate controls |
|
Production laboratory |
|
Face Volume (Face sagging, lips volume, eye bags)
|
Instrumental assessment of the efficacy on face volumes |
|
|
Objective |
To assess the face-volume efficacy of a product after single or repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration: 1 day or XX days (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Fringes projection analysis with Dermatop HE® or AEVA® |
|
Procedure |
Basal measurements Post treatment measurements of the same crow’s feet wrinkles/fine lines and cutometric measurements Analysis of the parameters Statistical comparison of the results obtained before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Measurement of the skin whitening (Colorimeter®) Intermediate controls |
|
Production laboratory |
|
Skin Regeneration
|
Title |
Instrumental assessment of the regenerating efficacy |
|
Objective |
To assess the regenerating efficacy (renewal of epidermal cells) of a product after repeated applications under normal conditions of use |
|
Schedule |
Duration of the study: 2-5 weeks Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Assessment of the cell turn-over by comparing the kinetics of decrease in skin colour obtained by application of DHA (Dihydroxyacetone) to a skin site treated with the product and to a control site by means of colorimetry (Mexameter® or Colorimeter® or Spectrophotocolorimeter®) |
|
Procedure |
Basal colorimetric measurements on 2 sites Application of a product containing DHA under patch on the 2 sites Colorimetric measurements after patch removal Daily application of the product to one pre-colored site Daily colorimetric measurements on test and control site until coloration has disappeared Statistical comparison of the results obtained from both test and control sites Optional: DHA test after treatment by the product under normal conditions of use Professional pictures before and after treatment |
|
Production laboratory |
|
Slimming
|
Title |
Instrumental assessment of the slimming efficacy |
|
Objective |
To assess the slimming efficacy of a product after repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: XX days (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Evaluation of slimming effect by fringe projection analysis AEVA®, weighing of the subjects and/or measurements of various body parts (thighs, waist, haunch…) in centimetres using a dressmaker meter |
|
Procedure |
Basal measurements of body weight and dimensions Use of the product at home by the subjects following the directions for use After treatment measurements of body’s weight and dimensions Statistical comparison of the results obtained before and after treatment Optional: Infra-red thermographic measurements (Infrared Camera ThermaCAM®B2) before and after treatment (EVIC France) Cosmetic qualities and efficacy questionnaire Intermediate controls |
|
Production laboratory |
|
Smoothing Effect / Orange Peel Aspect
|
Title |
Assessment of the smoothing effect / orange peel aspect |
|
Objective |
To assess the anti-cellulitis efficacy of a product after repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: XX days (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Clinical assessment of the state of the skin surface (“orange peel aspect”) on thighs according to an ordinal scale defined by the investigating centre and/or thermographic measurements (Infrared Camera ThermaCAM®B2), or fringes projection analysis AEVA® |
|
Procedure |
Basal clinical scoring and/or thermographic measurement Use of the product at home by the subjects following the directions for use Post treatment clinical scoring and/or thermographic measurement and/or AVEA® Statistical comparison of the results obtained before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Intermediate controls |
|
Production laboratory |
|
Self-Tanning Effect
|
Title |
Instrumental assessment of the self-tanning efficacy |
|
Objective |
To assess the self-tanning efficacy of a product after single/repeated application. Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: 1 or several days depending on the action mode of the product. Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Assessment of the skin colour induced by the product by means of colorimetric measurements (Mexameter® or Colorimeter® or Spectrophotocolorimeter®) |
|
Procedure |
Basal colorimetric measurements Single or repeated application of the product at the investigating centre Post treatment colorimetric measurements at different times in order to obtain the kinetics curve of the tan achieved Statistical comparison of the results obtained before and after treatment
Optional: cosmetic qualities and efficacy questionnaire |
|
Production laboratory |
|
Self-Tanning / Accelerating or Lasting
|
Title |
Instrumental assessment of the tanning accelerating effect and the lasting efficacy |
|
Objective |
To assess the tanning accelerating and/or lasting efficacy of a product after repeated application, simulating the use intention |
|
Schedule |
Duration of the study: 4 weeks Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Assessment of the speed of obtaining a skin tan by means of colorimetric measurements (Mexameter® or Colorimeter® or Spectrophotocolorimeter®) Assessment of the lasting tanning effect |
|
Procedure |
Determination of the theoretical lowest UVA dose capable of inducing an immediate and persistent minimal pigmentary response (MPPD) Basal measurement of the skin colour on 4 sites of the subjects’ back Repeated application of the product in 2 sites, once a day during 5 to 10 days, at the investigating centre Measurement of the skin colour on the 4 sites (test and control) delimited on the subjects’ back Induction of skin pigmentation in daily sessions of UVA radiations (Sun Simulator Multiport® -Solar Light Co) – 1 MPPD/day – during 3 to 5 days in 2 sites: one site with product application and one site without product application Colorimetric measurements on all 4 sites on both test (with and without radiation) and control sites (with and without radiation) each day of radiation For tanning accelerating effect: Repeated colorimetric measurements on all 4 sites 3 days later For lasting tanning effect: Repeated colorimetric measurements on all 4 sites every 3 days for 10 days Statistical comparison of the results obtained on both control and test areas Optional: Prolonged effect of the tan with additional product applications |
|
Production laboratory |
|
Sebo-Regulation / Sebum
|
Title |
Instrumental assessment of the sebo-regulating efficacy |
|
Objective |
To assess the efficacy of a product on the sebum secretion after repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: at least 28 days (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurement of the sebum secretion on the forehead using the Sebumeter® and Sebutape® or Sebufix® technique and analysis of the images with Quantiseb® or Visioscan VC 98® or Visioline® VL 650 or Skin Visiometer® SV 600 software |
|
Procedure |
Basal measurement of the sebum secretion Use of the product at home by the subjects following the instructions for use Post treatment measurements of the sebum secretion Statistical comparison of the results obtained before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Intermediate controls |
|
Production laboratory |
|
Sebum Rate / Matifying Effect
|
Title |
Instrumental assessment of the effect on the sebum rate / matifying efficacy |
|
Objective |
To assess the effect of a product on the sebum rate / matifying efficacy after single or repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: 1 day for immediate efficacy and at least 28 days for long term effect (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurement of the sebum rate using the Sebumeter®and/or glossymeter, Visia CR pictures analysis |
|
Procedure |
Immediate efficacy: Basal measurements on 2 sites Controlled application of the product to one site at the investigating centre Post treatment measurements on test and control sites (kinetics: 2h / 4h /8h /10h /12h) Statistical comparison of the results obtained before and after the treatment and on the control and test sites Long term efficacy: Basal measurements Use of the product at home by the subjects following the instructions for use Post treatment measurements Statistical comparison of the results obtained before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Intermediate controls Evaluation versus control product |
|
Production laboratory |
|
Comedolytic Effect
|
Title |
Clinical assessment of the comedolytic efficacy |
|
Objective |
To assess the comedolytic efficacy of a product after repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: at least 28 days Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Counting of the retentional and/or inflammatory elements |
|
Procedure |
Basal counting of the retentional and/or inflammatory elements on the forehead and cheeks or whole face Use of the product at home by the subjects following the instructions for use Post treatment count of the retentional and/or inflammatory elements (Comedolytic effect: capability to reduce the number of elements) Optional: Cosmetic qualities and efficacy questionnaire Professional pictures Statistical analysis of the data |
|
Production laboratory |
|
Lightening / Whitening
|
Title |
Instrumental assessment of the depigmenting efficacy on dark spots (including senescence spots) |
|
Objective |
To assess the depigmenting efficacy of a product after repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: 28 days (at least) – 56 days (advised) (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Assessment of the skin color of dark spots by colorimetric measurements using the Mexameter® or Colorimeter® or Spectrophotocolorimeter® or standardized photography with Visa CR® |
|
Procedure |
Basal colorimetric measurements of a distinctive dark spot and surrounding area Pictures with Visia CR® Use of the product at home by the subjects following the directions for use Post treatment colorimeter measurement of the same areas and pictures Statistical comparison of results obtained (Mexameter®: melanic index / Spectrophotocolorimeter® or Colorimeter®: L*= brightness (luminescence) and “ITA°”= individual typological angle parameters) before and after treatment Analysis of the picture Optional: Cosmetic qualities and efficacy questionnaire Professional pictures before and after treatment Intermediate controls |
|
Production laboratory |
|
Hygiene Products
Moisturization
|
Title |
Instrumental assessment of the immediate or cumulative moisturizing efficacy |
|
Objective |
To assess the efficacy of a product on the hydration level of the upper layers of the epidermis after single or repeated applications Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: 1 day for immediate efficacy and XX days for cumulative efficacy. (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurement of the skin capacitance using Corneometer®, Moisturemeter®D and/or skin water content. Picture with Visioscan® V98 |
|
Procedure |
Immediate efficacy: Basal corneometric measurements on 2 sites Controlled application of the product to one site Post treatment corneometric measurements on test and control sites (kinetics: 30 min. / 2h / 4h / 6h / 8h /10h /12h /24h and/or 48h) Statistical comparison of the results obtained on the control and test sites at each experimental time Cumulative efficacy: Basal corneometric measurements Use of the product at home by the subjects following the instructions for use. Post treatment corneometric measurements Statistical comparison of the results obtained before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Intermediate controls |
|
Production laboratory |
|
Skin Barrier Function / Protection
|
Title |
Instrumental assessment of the efficacy on the skin barrier function |
|
Objective |
To assess the effects of a product on the skin barrier function after single or repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: XX days (Optional: intermediate controls) Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurement of the transepidermal water loss (TEWL) (Tewameter® or VapoMeter®, or Evaporimeter Ep-1) reflecting stratum corneum barrier functions |
|
Procedure |
Immediate efficacy: Basal TEWL measurements on 2 sites Controlled application of the product to one site Post treatment TEWL measurements on test and control sites (kinetics: 30 min. / 2h / 4h / 6h / 8h /10h /12h 24h and/or 48h) Statistical comparison of the results obtained on the control and test sites at each experimental time Cumulative efficacy: Basal TEWL measurements Use of the product at home by the subjects following the instructions for use. Post treatment TEWL measurements Statistical comparison of the results obtained before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Intermediate controls |
|
Production laboratory |
|
Peeling / Exfoliating Effect
|
Instrumental assessment of the peeling/exfoliating efficacy |
|
|
Objective |
To assess the peeling/exfoliating efficacy of a product after single application |
|
Schedule |
Duration of the study: 1 day Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Determination of the desquamation index based on the analysis of the scales extracted from the skin (D-Squame® & Quantisquames® software, or Corneofix® technique & Visioscan VC 98®, Skin Visiometer® or Visioline® VL 650 software) |
|
Procedure |
Basal skin stripping with D-Squame® or Corneofix® adhesives on 2 sites Single application of the product at the investigating centre to one site Post treatment skin stripping on both test and control sites Statistical comparison of the results obtained before and after treatment |
|
Production laboratory |
|
Deodorant – Sniff Test
|
Title |
Olfactive assessment of the deodorant efficacy, Sniff test |
|
Objective |
To assess the deodorant efficacy of a product after single application |
|
Schedule |
Duration of the study: 2-3 days after a wash-out period Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Olfactive assessment of the body odour by trained and qualified examiner(s) |
|
Procedure |
Washing of both armpits of the subjects with neutral soap Olfactive assessment of both armpits Controlled application of the product to one of the armpits Olfactive assessment at different times (4h and/or 6h and/or 8h and/or 24h and/or 48h) of both armpits (test and control) Statistical comparison of the results obtained on the test and control sites at each experimental time Optional: Possibility to adapt this technique to feet Microbiological analysis |
|
Production laboratory |
|
Deodorant – Anti-white Marks
|
Title |
Assessment of the non-transfer ability of the product (i.e. white marks transfer to the clothes) |
|
Objective |
To assess the ability of a deodorant not to lead to white marks on clothes after a single application under controlled conditions |
|
Schedule |
Duration of the study: 1 day Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Clinical assessment to black clothes by a trained assessor in 20 volunteers |
|
Procedure |
Application of the product to one armpit,under standard conditions To the contro-lateral armpit, application of a negative reference (not leaving any white mark) Leave-on time The volunteer is asked to put on a standard thigh t-shirt in 100% black cotton Then the shirt is removed and graded by a clinical trained assessor for its white marks to both right and left sides Option : The volunteers stay 2 hours at the center, wear a large suit, then the methodology is carried out again 2 hours later |
|
Production laboratory |
|
Dedodorant – Anti-Yellow Marks
|
Title |
Assessment of the anti-yellow stains efficacy of deodorant |
|
Objective |
To assess the ability of a deodorant not to lead to yellow marks on clothes after repeated applications and washing of the clothes |
|
Schedule |
Duration of the study: 21 days Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Clinical assessment to white clothes by a trained assessor in 20 volunteers |
|
Procedure |
Application of the product to one armpit,under standard conditions, everyday, by the subject, at home To the contro-lateral armpit, application of a known negative reference (not leaving any yellow mark). The volunteer is aked to wear a a standard thight t-shirt in 100% white cotton, everyday, for 21 days,under her/his clothes (2 peces provided) and to wash it in a regular way under specific given conditions (detergent, temperature etc…) Then the shirts are brought back after 21 days and graded by a clinical trained assessor for their yellow marks to both right and left sides |
|
Production laboratory |
|
Antiperspirant - Gravimetry
|
Title |
Assessment of the antiperspirant efficacy |
|
Objective |
To assess the efficacy of a product on the excretion by the sweat glands after repeated applications Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: 5-28 days after a 17 day wash-out period Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Gravimetric assessment: weighing of collected sweat based on the FDA method |
|
Procedure |
Aggravated sudation period in an overheated room for 2 periods of 20 minutes with pads placed under each armpit of the subjects Weighing of collected sweat pads Wash of armpits with a neutral soap Application of the product to one armpit Use of the product at home following the directions for use on one armpit for 5 to 28 consecutive days Gravimetric measurements in the same previous conditions on both armpits Statistical comparison of the results obtained on test and control sites before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Daily application of the product at the investigating centre Additional gravimetric measurements Possibility to adapt this technique to feet |
|
Production laboratory |
|
Antiperspirant - TEWL
|
Title |
Assessment of the antiperspirant efficacy |
|
Objective |
To assess the efficacy of a product on the excretion by the sweat glands after single application |
|
Schedule |
Duration of the study: 1 day Beginning: 2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurement of the trans-epidermal water loss by means of Tewameter® or VapoMeter®, or Evaporimeter® |
|
Procedure |
Basal measurements of the TEWL on each armpit Application of the product to one armpit at the investigating centre 8 hours after application of the product: measurement of the TEWL on both test and control armpits Statistical comparison of the results obtained on test and control sites before and after treatment Optional: Additional measurements |
|
Production laboratory |
|
Hair Care
Efficacy of Haircare products by hairdressers
|
Title |
Assessment of the hair care products efficacy by professional hairdressers |
|
Objective |
The objective will depend on the requested efficacy measurement |
|
Schedule |
Duration of the study: will depend on the study Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Please contact us for detailed offer |
|
Procedure |
The procedure will depend on the requested efficacy measurement |
|
Production laboratory |
|
Anti-Hair Loss / Hair Regrowth
|
Title |
Instrumental assessment of the anti-hair loss/hair regrowth efficacy |
|
Objective |
To assess the anti-hair loss/hair regrowth efficacy of a product versus placebo, in single or double blind, after repeated application under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: depending on the product (minimum advised: 3 months of treatment) Beginning: 3/4 weeks upon receipt of the samples Report: 4 weeks after the end of the study |
|
Methodology |
Counting of anagen and telogen hair and/or examination of the hair diameter and growth rate and/or scoring of the scalp and hair characteristics using the technique of phototrichograms |
|
Procedure |
Basal phototrichogram and/or examination of the hair diameter and growth rate and/or scoring of the scalp and hair characteristics 1st application of the product and placebo at the Investigating center Use of the product or placebo at home by the subjects following the instructions for use Post treatment phototrichogram and/or examination of the hair diameter and growth rate and/or scoring of the scalp and hair characteristics Statistical comparison of the results obtained before and after treatment for each product Optional: Cosmetic qualities and efficacy questionnaire Application of the product and placebo at the investigating centre under controlled conditions Intermediate controls |
|
Production laboratory |
|
Anti-Dandruff
|
Title |
Assessment of the anti-dandruff efficacy |
|
Objective |
To assess the anti-dandruff efficacy of a product after repeated applications under normal conditions of use Optional: To assess subjectively its cosmetic qualities and efficacy |
|
Schedule |
Duration of the study: depending on the product (at least 14 days of treatment) Beginning: 3 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Clinical assessment of the dandruff state according to the ordinal scale defined by the investigating centre and/or gravimetric measurements (weighing of dandruff collected from the rinsing water) |
|
Procedure |
Basal scoring of the dandruff state and/or gravimetric measurements Use of the product at home by the subjects following the instructions for use Post treatment scoring of the dandruff state and/or gravimetric measurements Statistical comparison of the results obtained before and after treatment Optional: Cosmetic qualities and efficacy questionnaire Study versus placebo Application at the investigating centre under controlled conditions Intermediate controls Controlled wash-out period before treatment |
|
Production laboratory |
|
Sun Care
Sun Protection Factor (SPF)
|
Title |
Assessment of the Sun Protection Factor according to the ISO 24444 and FDA 2011 |
|
Objective |
To define the sun protection level of a product by the calculation of the sun protection factor (SPF) |
|
Schedule |
Duration of the study: 1-2 weeks depending on the stages chosen by the Sponsor Beginning: 1-2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Clinical assessment of the skin erythemal response to ultraviolet radiation (Sun Simulator Multiport®) |
|
Procedure |
Determination of the theoretical Minimal Erythema Dose (MED) to define the UV exposure time Application of the product and reference product to the back of the subjects Determination of the current Minimal Erythemal Dose (MED) UV exposure 15-30 minutes after application Skin examination 16 to 24 hours after UV exposure: clinical assessment Optional: SPF determination according to FDA final monograph (1999) / Australian/New Zealand standard recommendations (AS/ZNS 26094: 1998) Screening or full study performance |
|
Production laboratory |
|
Sun Protection Factor + Water Resistance (SPF + WR)
|
Title |
Assessment of the Sun Protection Factor according to the ISO 24444 and Assessment of Water Resistance according to the COLIPA GUIDELINES FOR EVALUATING SUN PRODUCT WATER RESISTANCE -December 2005 |
|
Objective |
To define the sun protection level of a product by the calculation of the sun protection factor (SPF) and to assess its water resistance (WR) by means of the calculation and comparison of the SPF before immersion into water and after an immersion period. |
|
Schedule |
Duration of the study: 1-2 weeks depending on the stages chosen by the Sponsor Beginning: 1-2 weeks upon receipt of the samples Report: 3-4 weeks after the end of the study |
|
Methodology |
Clinical assessment of the skin erythemal response to ultraviolet radiation (Sun Simulator Multiport®) before and after immersion into water |
|
Procedure |
Determination of the theoretical Minimal Erythemal Dose (MED) to define the UV exposure time Shower of the subjects Application of the product to the back of the subjects on the immersed site Jacuzzi (2 x 20 minutes) UV exposure of the immersed site Application of the product and reference product on non-immersed sites Determination of the current MED UV exposure 15-30 minutes after application Skin examination 16 to 24 hours after UV exposure: clinical assessment Optional: Very Water Resistance test (Jacuzzi 4 x 20 minutes) |
|
Production laboratory |
|
p-UVA
|
Title |
Assessment of the Protection Factor against ultraviolet A radiation (UVA) according to the UVA ISO 24442 |
|
Objective |
To define the sun protection level of a product by the calculation of the UVA sun protection factor (PFA) |
|
Schedule |
Duration of the study: 1-2 weeks depending on the stages chosen by the Sponsor Beginning: 1-2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Clinical assessment of the skin pigmentary response to UVA ultraviolet radiation (Sun Simulator Multiport®) |
|
Procedure |
Determination of the theoretical lowest UVA dose capable of inducing an immediate and persistent minimal pigmentary response (MPPD) Application of product and reference product to the back of the subjects UV exposure 15-30 minutes after application Skin examination between 2 and 4 hours after UV exposure (according to the expected PFA value): clinical assessment |
|
Production laboratory |
|
Oral Care
Teeth Whitening
|
Title |
Assessment of the teeth whitening |
|
Objective |
To assess the skin whitening and the efficacy of a product after single or repeated application(s) under normal conditions of use |
|
Schedule |
Duration of the study: 1 days or X days Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Instrumental analysis of the teeth whitening on UV pictures with Visia CR® or Nikon® D300 Micro Nikkor AF-S 105mm and clinical scoring by a dentist |
|
Procedure |
Basal picture and clinical scoring (using shade grading system) Single or repeated use Analysis of the whitening effect |
|
Production laboratory |
|
Anti-Plaque
|
Title |
Assessment of the anti-plaque efficacy |
|
Objective |
To assess the anti-plaque activity of a product after single or repeated application(s) under normal conditions of use |
|
Schedule |
Duration of the study: 1 day or X days Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurements of the FMPS (Full-Mouth Plaque Score), of the Plaque Index (PI) and of the Gingival Index (GI) Evaluation of visible plaque with disclosing tablets Pictures of the teeth with Nikon d300 Micro Nikkor AF-S 105 mm |
|
Procedure |
Pictures and clinical scoring before and after the treatment Single or repeated use Analysis of the anti-plaque effect |
|
Production laboratory |
|
Anti-Tartar
|
Title |
Assessment of the anti-tartar efficacy |
|
Objective |
To assess the anti-tartar activity of a product after single or repeated application(s) under normal conditions of use |
|
Schedule |
Duration of the study: 1 day or X days Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurements of the CSI (Calculus Surface Index) and of the Gingival Index (GI) Pictures of the theets with Canon Powershot G6 |
|
Procedure |
Pictures and clinical scoring before and after the treatment Single or repeated use Analysis of the anti-tartar effect |
|
Production laboratory |
|
Teeth Hypersensitivity
|
Title |
Assessment of the efficacy against teeth hypersensitivity |
|
Objective |
To assess the activity of a in reducing teeth hypersensitivity after single or repeated application(s) under normal conditions of use |
|
Schedule |
Duration of the study: 1 day or X days Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurements of teeth sensitivity to warm and cold stimulus by VAS (Visual Analogue Scale) and objective evaluation (clinical scoring) |
|
Procedure |
VAS and clinical scoring before and after the treatment Single or repeated use Analysis of the teeth hypersensitivity reduction effect |
|
Production laboratory |
|
Anti-Bacterial (Mouth)
|
Title |
Assessment of the antibacterial efficacy on the mouth |
|
Objective |
To assess the antibacterial activity of a product after single or repeated application(s) under normal conditions of use |
|
Schedule |
Duration of the study: 1 day or X days Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Quantification of periodontal bacteria |
|
Procedure |
Periodontal DNA test kit (Curaden) before and after the treatment Single or repeated use Analysis of the anti-bacterial effect The procedure may be different depending on the laboratory |
|
Production laboratory |
|
Anti-Halitosis
|
Title |
Assessment of the anti-halitosis efficacy |
|
Objective |
To assess the anti-halitosis activity of a product after single or repeated application(s) under normal conditions of use |
|
Schedule |
Duration of the study: 1 day or X days Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Measurements of the VSC (Volatile Sulphur Compounds), by Halimeter® |
|
Procedure |
Measurements of the VSC before and after the treatment Single or repeated use Analysis of the anti-halitosis effect The procedure may be different depending on the laboratory |
|
Production laboratory |
|
Make-up
Waterproof
|
Title |
Assessment of the Waterproof efficacy |
|
Objective |
To assess the waterproof efficacy of a product, after a single and standardized application, and standardized pulverisations, under controlled conditions |
|
Schedule |
Duration of the study: 1 day Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Clinical scoring by a beautician |
|
Procedure |
Product application by a beautician, according to a right-left randomization 15 minutes of leave-on time Water pulverization Clinical assessment by a beautician |
|
Production laboratory |
|
Smudgeproof
|
Title |
Assessment of the anti-smudge efficacy |
|
Objective |
To assess the anti-smudge efficacy of a product, after a single and standardized application, under controlled conditions |
|
Schedule |
Duration of the study: 1 day Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Clinical scoring by a beautician |
|
Procedure |
Product application by a beautician, according to a right-left randomization 15 minutes of leave-on time Facial sauna which releases steam at 42°C, during 6 minutes Clinical assessment by a beautician |
|
Production laboratory |
|
Long Lasting
|
Title |
Assessment of the long lasting efficacy |
|
Objective |
To assess the long Lasting efficacy of a cosmetic product after a single and standardized application |
|
Schedule |
Duration of the study: 1 day or X days Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Instrumental analysis of the lasting on pictures with Visia CR® and clinical scoring by a beautician |
|
Procedure |
Application of the product by a beautician Basal picture and clinical scoring (using analogical scale) Rest period of the volunteers (controlled conditions) Pictures on different kinetics Tx Analysis of the lasting using the Kalliste software (lasting of the made-up surface) or Colorskin Software (color lasting) Analysis of the lasting by clinical scoring The procedure may be different depending on the laboratory |
|
Production laboratory |
|
Make-up Removal
|
Title |
Assessment of the make-up removal efficacy |
|
Objective |
To assess the make-up removal efficacy of a product after a single and standardized application |
|
Schedule |
Duration of the study: 1 day Beginning: 2 weeks upon receipt of the sample Report: 3-4 weeks after the end of the study |
|
Methodology |
Clinical scoring by a beautician and assessment of the cosmetic qualities of the product by the volunteers using a suitable questionnaire |
|
Procedure |
Application of 3 or 4 make-up products by a beautician Leave-on time of 15 minutes Make-up removal of an half-face by a beautician Clinical assessment by a beautician Make-up removal of the other half-face by the volunteer Assessment of the cosmetic qualities by the volunteer |
|
Production laboratory |
|
Experts Scoring on all product types
|
Criteria |
|
|
Skin Face – body
|
Smoothness Softness Dryness Firmness Texture (pores) Matifying effect Imperfections Redness Cellulite Stretch marks Wrinkles Suppleness Radiance Long lasting of foundation |
|
Teeth |
Whitening effect Tartar scoring Removal of dental plaque Stain scoring |
|
Eyes
|
Dark circles under the eyes Bags under the eyes Long lasting of makeup (Eye shadow, mascara, eye liner) |
|
Hair
|
Dandruffs Regrowth Anti-hair loss Depilatory (velocity and quality of the hair regrowth) Bleaching effect |
|
Nails
|
Coating effect Long lasting effect of nail enamel Brightness Ribbed Softness Brittleness Split scoring |
|
Lips:
|
Long lasting effect of make up Dryness Volume |
|
Feet |
Dryness Crack scoring Callosity scoring |
