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Services >> In Vitro Pharmacology >> Proteases

Solutions for protease screening and profiling

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Proteases are a class of enzymes which perform proteolysis, the mechanism of digesting or cleaving long chain proteins into smaller fragments by severing the peptide bonds that hold them together. Trypsin, a serine protease secreted by the pancreas, is commonly used in cell tissue culture to cleave the bonds that cells use to adhere to a flask.

Proteases also play a major role in disease.  HIV-1 protease is essential to the viral replication process. MMP-9, a matrix metallopeptidase, plays a role in angiogenesis and is a therapeutic target for cancer.  Because of their significance in the pathology of disease, proteases are a relevant drug target class.

Our broad portfolio of over 50 proteases spanning across the serine, cysteine, aspartic, and metalloprotease families was designed with you in mind to facilitate your drug discovery process and provide you with the answers you need.

Over 50 targets to support your research, including these families and targets:

  • Families
    • Metalloprotease
    • Caspase
    • Cathepsin
  • Targets of interest
    • HIV-1 protease
    • Proteasome
    • DDP4...and many other peptidases