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FlexLab™ Custom Assay Development Services

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Custom assays to support your drug discovery project

Eurofins has built its reputation as a comprehensive, all-in-one provider of discovery assays to take your project from library to preclinical candidate. While we have worked diligently to ensure our assay catalog has everything necessary to support your drug discovery program, we also understand that standard off-the-shelf assays may not have the parameters you require.

Fortunately, Eurofins is able to provide custom assays by modifying existing assays and creating new assays that are tailored to your needs. Our dedicated scientists, who have developed thousands of binding, enzymatic, cell based and in vivo assays, are always available to help work through your assay design and provide a step-by-step plan for your experiment. By trusting Eurofins with your custom assay needs, you're ensuring your project has the greatest chance  for success.

Some of the available platforms to design your custom assays around:

  • High Content Imaging
    • MD ImageXpress® Micro
  • Electrophysiology platforms
    • IonFlux™ HT
  • Mass spectrometers
    • Agilent RapidFire 365
  • Plate readers
    • FLIPRTETRA® plus ICCD system
    • Perkin Elmer EnVision®
    • BMG PHERAStar® FS
  • Multiplex immunoassays
    • MSD® Sector® Imager
  • Scintillation counting
    • PerkinElmer 1450 MicroBeta® TriLux
  • Automation and liquid handling
    • Labcyte Echo®
    • Biomek® FXP / NX
    • Agilent BioCel 1200
  • Cell preparation
    • MaxCyte® STX®
    • Vi-CELL®
  • For a full list click here


Figure 1. Generation of a HTRF® binding assay to detect MDM2-p53 interactions.

During assay optimization, a series of iterative experiments were carried out, titrating each of the binding assay components: cMyc-tagged p53, GST-tagged MDM2, europium-labeled anti-GST antibody and allophycocyanin-conjugated anti c-Myc antibody. Binding between p53 and MDM2 brings the donor and acceptor fluorophores into close proximity, allowing an energy transfer complex to form, resulting in time-resolved FRET signal.