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Cell Based Phenotypic >> Oncology >> Large Molecule Biologics

Large molecule biologics

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The types of therapeutics used to treat cancer are the most diverse among therapeutic areas. Of growing success and interest has been large molecule therapeutics for oncology, especially humanized monoclonal antibodies (mAbs). MAbs are generally targeted to cell surface receptors, or the ligands of these receptors, to block various oncogenic hallmarks (e.g., uncontrolled cell proliferation). OncoPanel™ services can help profile cell surface antigen expression for a mAb's target and identify drug responsiveness in the same assay.

OncoPanel™ services at work for biologics:

  • One assay, many outputs
    • Drug response
    • Kd for therapeutic antibodies
    • Cell surface antigen expression profiles in live cells
  • Antibody-drug conjugates (ADC) assessment
    • Internalization of naked antibody



Figure 1. Detection of endogenous protein expression of EGFR and HER2 across the eight human tumor.