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Preclinical Models from Pharmacology Discovery Services

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Anti-Infectives/Microbiology Inflammation/Allergy Cardiovascular CNS / Pain
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Gastrointestinal/Renal Oncology Metabolic/Endocrine Respiratory
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 DMPK  Safety    

Trust the experts at our Partner Lab, Pharmacology Discovery Services, with the preclinical assessment of your most promising candidates

Our Partner Lab, Pharmacology Discovery Services, has a long and successful history of creating and testing  models to evaluate the pharmacological effects of drug candidates in all major therapeutic categories with emphasis on anti-infectives, inflammation/allergy, CNS/pain and oncology.

Their portfolio provides progressive evaluation of your study from tolerability and exposure through all levels of pharmacodynamics, including primary screening for activity and rank-ordering, lead identification, candidate selection, disease-specific efficacy and dose-dependent proof-of-concept in relevant translational studies.

They provide therapeutically focused disease models, incorporating biomarkers and outcome measures that enable greater prediction of clinical success.  All in vivo studies are supported by a dedicated team of global Technical Directors specializing in specific therapeutic areas.  The scientific experts at Pharmacology Discovery Services, with their years of pharmaceutical drug development expertise, provide you ongoing project oversight, with prompt communication and a commitment to on-time reporting, enabling you to meet your strict drug-development timelines.

The expert laboratory staff can formulate and dose test articles by virtually any route, including short- or long-term continuous infusion, and can monitor blood, brain, tissue and/or CSF exposure for PK/PD studies, as well as conduct biomarker analyses. Technical and Study Directors are readily available for consultations, allowing custom study designs to meet your budgetary needs.  

Advantages of in vivo testing with our Partner Lab, Pharmacology Discovery Services:

  • Highly experienced scientific staff - average experience of 15 years
  • Experimental design guided by Technical Director staff with Pharma experience
  • Experience with therapeutics of every type
    • Biologics, vaccines, RNAi, liposomal formulations, nanoparticles, cellular agents or small molecule NCEs.
  • Flexible formulation and dosing options to meet any need
    • Standard methods: ID, IM, IN, IP, IT, IV, PO, SC, topical
    • Short and long term continuous IV infusion
    • Adjustable dose schedule: qd, bid, tid, qid
    • Formulation optimization services available
  • Ancillary services:
    • Clinical chemistry, hematology, blood gases, surgery, bioassay, necropsy, gross pathology, exposure (PK)
  • Consultative, custom model development with wildtype or genetically modified models