In Vitro Pharmacology >> Bioinformatics >> BioPrint

Determine your drug’s similarity to existing drugs with BioPrint®

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BioPrint® is a large, homogenous pharmacology and ADME database, which provides a unique resource for supporting the drug discovery decision-making process. The database is composed of three main data sets:

  • Chemical descriptors (structures and chemical information, 2D- and 3D- descriptors)
  • In vitro data
  • Collected and curated in vivo effects of drugs

Our standard BioPrint® profile includes the assays used to explore the properties of >2,500 BioPrint® compounds (consisting of marketed drugs and reference compounds), which establishes individual Pharma-ADME fingerprints for each compound.  

BioPrint® positions a new drug candidate in the context of marketed drugs, allowing you to anticipate potential in vivo liabilities, predicting off-target activities, and ADME characteristics (drug profile interpretation). BioPrint® can also help identify secondary therapeutic targets that are not genetically related to a test target (target profile design) for drug repositioning.

Advantages of a BioPrint® profile:

  • Includes a panel of:
    • 104 binding assays (non-peptide, peptide and nuclear receptors, ion channels and amine transporters)
    • 31 enzyme assays (including 10 kinases, 10 proteases and 5 PDEs)
  • Identify marketed drugs and reference compounds with similar pharmacological profiles or sub-profiles to that of a test compound
  • Hypothesize clinical effects of new drug candidates based on the well characterized in vivo effects of drugs with similar profiles
  • Place individual hits on a test compound in the context of similar strength hits on marketed drugs and reference compounds

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Figure 1: BioPrint® profile heatmap of benzodiazepine receptor interactors