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Services >> Efficacy >> CNS / Pain

Exploring the in vivo efficacy of your CNS/Pain candidates

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The central nervous system (CNS) is prone to many diseases and pain-related disorders, especially prevalent during aging. The importance of CNS disorders is indicated by the severity of many of the diseases associated with it. These diseases include depression, epilepsy, psychosis, multiple sclerosis, and many other common, yet difficult-to-treat diseases.

Eurofins Pharma Discovery Services has conducted in vivo testing for CNS and Pain disorders for both efficacy and side-effect profiling for over 30 years.  We have applied in vivo and neuroscience acumen to develop the most relevant CNS and pain-related models including epilepsy, affective disorders, neuroleptic, and multiple sclerosis, acute, inflammatory and neuropathic pain.  We also offer translational models of pain such as osteoarthritis and bone cancer pain, a testament to our superlative skills. Additionally, several pain-associated behavioral measurements such as mechanical allodynia, thermal and mechanical hyperalgesia, as well as cold allodynia are available.

Advantages of CNS/Pain studies with Eurofins:

  • >50 CNS and pain assay models available
  • Models include:
    • Analgesia / pain
      • Acute, inflammatory & neuropathic pain
    • Epilepsy / convulsions
    • Affective disorders
      • Anxiety
      • Depression
      • Antipsychotic/neuroleptic
    • Multiple sclerosis
    • Motor activity
  • Models are qualified in a dose-dependent manner with approved benchmark positive controls.
  • Companion services can monitor blood, brain, spinal cord and/or CSF exposure and biomarker analysis for PK/PD assessment.